Target intelligence / Profile preview

Phosphodiesterase 4 (PDE4)

Target: PDE4
Molecular classification: Enzyme, Phosphodiesterase, Phosphoric diester hydrolase

Overview

Phosphodiesterase 4 (PDE4) is an intracellular enzyme that specifically hydrolyzes cyclic adenosine monophosphate (cAMP), a key second messenger involved in regulating numerous physiological processes such as inflammation, immune responses, neural activity, learning, and memory. Inhibition of PDE4 leads to increased intracellular cAMP levels with anti-inflammatory effects, which underpins its therapeutic use for several diseases.

Other names: Type 4 cAMP phosphodiesteraseDPDE44PDE4APDE4BPDE4CPDE4D

Mechanism of action

Inhibition of PDE4 leads to increased intracellular cAMP levels, resulting in anti-inflammatory and other effects.

Biological functions

Hydrolyzes cAMP to AMPRegulation of intracellular cAMP levelsModulation of inflammatory responsesRegulation of immune cell activation and migrationRegulation of neuronal excitability and synaptic plasticityRegulation of vascular smooth muscle proliferation/relaxationRegulation of myocardial contraction

Disease associations

Pulmonary diseasesAsthmaChronic obstructive pulmonary diseaseDermatological conditionsPsoriasisAtopic dermatitisNeurological disordersMild neurocognitive disorderPsoriatic arthritisInflammation

Safety considerations

NauseaEmesisGastrointestinal symptoms

Interacting drugs

Roflumilast

2 more in the full profile.

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