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Target intelligence / Profile preview
Phosphodiesterase 4A (PDE4A)
- Target
- PDE4A
- Molecular classification
- Enzyme, Phosphoric diester hydrolase, Cyclic nucleotide phosphodiesterase
01
Overview
Phosphodiesterase 4A (PDE4A) is an enzyme that hydrolyzes cyclic adenosine monophosphate (cAMP), thereby regulating intracellular levels of cAMP. It plays a key role in various physiological processes such as inflammation, memory formation, and emotional regulation. Implicated in inflammatory diseases such as asthma and psychiatric disorders like anxiety or depression. Low expression linked to progression of certain cancers such as ovarian cancer.
- Other names
- DPDE2Type IVB-specific phosphodiesterasecAMP-specific phosphodiesterase type IVAPDE46
02
Mechanism of action
Inhibition of PDE4A leads to increased intracellular cAMP levels.
03
Biological functions
Hydrolysis of cAMPRegulation of signal transductionModulation of cellular responses to extracellular signalsRegulation of intracellular cAMP levels
04
Disease associations
AsthmaInflammationPsychiatric disordersAnxietyDepressionOvarian cancer
05
Interacting drugs
Rolipram
3 more in the full profile.
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