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Target intelligence / Profile preview
Phosphodiesterase 4A1 (PDE4A1)
- Target
- PDE4A1
- Molecular classification
- Enzyme, Cyclic nucleotide phosphodiesterase, PDE4 subfamily
01
Overview
Phosphodiesterase 4A1 (PDE4A1) is an enzyme that hydrolyzes cAMP, a key regulator and mediator of numerous cellular responses to extracellular signals. By controlling cAMP levels, it plays a central role in regulating physiological processes such as immune cell function, learning and memory, anxiety regulation, and cardiovascular signaling. PDE4A1 contains a unique N-terminal region crucial for intracellular targeting and membrane association. It is a therapeutic target for anti-inflammatory and antidepressant drugs.
- Other names
- DPDE2PDE4PDE46phosphodiesterase 4A[3]
02
Mechanism of action
Inhibition of cAMP hydrolysis
03
Biological functions
Regulation of cAMP levelsImmune cell functionLearning and memoryAnxiety regulationCardiovascular signaling
04
Disease associations
InflammationNeurological disordersCardiovascular disease
05
Interacting drugs
Rolipram
4 more in the full profile.
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