Target intelligence / Profile preview

Phosphodiesterase 4A1 (PDE4A1)

Target: PDE4A1
Molecular classification: Enzyme, Cyclic nucleotide phosphodiesterase, PDE4 subfamily

Overview

Phosphodiesterase 4A1 (PDE4A1) is an enzyme that hydrolyzes cAMP, a key regulator and mediator of numerous cellular responses to extracellular signals. By controlling cAMP levels, it plays a central role in regulating physiological processes such as immune cell function, learning and memory, anxiety regulation, and cardiovascular signaling. PDE4A1 contains a unique N-terminal region crucial for intracellular targeting and membrane association. It is a therapeutic target for anti-inflammatory and antidepressant drugs.

Other names: DPDE2PDE4PDE46phosphodiesterase 4A[3]

Mechanism of action

Inhibition of cAMP hydrolysis

Biological functions

Regulation of cAMP levelsImmune cell functionLearning and memoryAnxiety regulationCardiovascular signaling

Disease associations

InflammationNeurological disordersCardiovascular disease

Interacting drugs

Rolipram

4 more in the full profile.

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