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Phosphodiesterase 4C (PDE4C)
- Target
- PDE4C
- Molecular classification
- Enzyme, Phosphodiesterase, Phosphoric diester hydrolase, 3',5'-cyclic-nucleotide phosphodiesterase
01
Overview
PDE4C encodes an enzyme that specifically degrades cAMP—a critical second messenger—in peripheral tissues. It plays essential roles across diverse physiological systems but remains less characterized than other members of its family due to limited distribution and lack of specific pharmacological tools or inhibitors at present.
- Other names
- DPDE1PDE21phosphodiesterase type IV-C
02
Mechanism of action
Hydrolysis of cAMP to AMP
03
Biological functions
Signal transductionRegulation of cAMP levelsModulation of cardiovascular functionInfluence on immune responsesRegulation of endocrine/exocrine gland functionGrowth regulationMetabolism
04
Disease associations
Cancer
05
Safety considerations
Lack of highly selective clinical inhibitorsLimited research tools compared to other PDE4 subfamilies
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