Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Phosphodiesterase 5 (PDE5)
- Target
- PDE5
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
Phosphodiesterase 5 (PDE5) is an enzyme that hydrolyzes cyclic GMP (cGMP), regulating intracellular cGMP levels. It is a therapeutic target for erectile dysfunction and pulmonary hypertension, with inhibitors like sildenafil and tadalafil increasing cGMP levels to promote vasodilation.
02
Mechanism of action
Inhibition of PDE5 activity, leading to increased cGMP levels and vasodilation.
03
Biological functions
Hydrolysis of cGMPRegulation of smooth muscle toneVasodilation regulationRegulation of intracellular cGMP levelsCalcium homeostasisNeurotransmission
04
Disease associations
Erectile dysfunctionPulmonary hypertensionCardiovascular diseases (potential)Chronic kidney disease (potential)Diabetes mellitus (potential)
05
Safety considerations
HypotensionHeadacheFlushingDyspepsiaNasal congestionVisual disturbancesPriapism
06
Interacting drugs
Sildenafil
7 more in the full profile.
Beyond the preview
Go deeper on Phosphodiesterase 5 (PDE5).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Phosphodiesterase 5 (PDE5).