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Target intelligence / Profile preview
Phosphodiesterase 5A (PDE5A)
- Target
- PDE5A
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
Phosphodiesterase 5A (PDE5A) is an enzyme that hydrolyzes cyclic GMP (cGMP), regulating its intracellular concentration. It plays a key role in vascular tone, smooth muscle relaxation, and other physiological processes. PDE5A inhibitors are used to treat erectile dysfunction and pulmonary hypertension, and are being investigated for cardiovascular and cancer therapies.
02
Mechanism of action
PDE5A inhibitors bind with high affinity at the catalytic site of PDE5A, enhancing NO effects through increased cGMP levels.
03
Biological functions
Regulation of vascular toneModulation of NO/cGMP pathwayHydrolyzes cyclic GMP to 5'-GMPSignal transductionSmooth muscle relaxation
04
Disease associations
Erectile dysfunctionPulmonary hypertensionCardiovascular diseaseCardiac failureCancer
05
Interacting drugs
Sildenafil
3 more in the full profile.
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