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Target intelligence / Profile preview
Phosphodiesterase 7 (PDE7)
- Target
- PDE7
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
Phosphodiesterase 7 (PDE7) is a member of the phosphodiesterase superfamily that specifically hydrolyzes cyclic adenosine monophosphate (cAMP), playing a crucial role in regulating intracellular cAMP signaling pathways. It exists as two main isoforms, PDE7A and PDE7B, with various splice variants. PDE7 is predominantly found in the central nervous system (CNS) and immune cells. By regulating cAMP levels, PDE7 impacts T cell activation, neurogenesis, synaptogenesis, and memory formation. Increased expression or activity of PDE7 has been implicated in several diseases, including Parkinson’s disease, Alzheimer’s disease, multiple sclerosis and various cancers, making it an attractive drug target, particularly for CNS disorders and inflammatory diseases. Common inhibitors include IBMX and papaverine, but isozyme-selective inhibitors are under development.
02
Mechanism of action
Inhibition of cAMP hydrolysis
03
Biological functions
Regulation of cAMP levelsSignal transductionRegulation of T cell functionNeurogenesisSynaptogenesisMemory formation
04
Disease associations
Parkinson’s diseaseAlzheimer’s diseaseHuntington’s diseaseMultiple sclerosisChronic obstructive pulmonary disease (COPD)Cancer
05
Safety considerations
Potential off-target effects due to non-selective inhibitorsDevelopment of isozyme-selective inhibitors needed to minimize adverse reactions
06
Interacting drugs
IBMX (3-isobutyl-1-methylxanthine)
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