Phosphodiesterase 7 pseudogene

Phosphodiesterase 7 pseudogene (ENSG00000268582) is a *pseudogene* in the human genome, annotated on databases such as GeneCards as a "Phosphodiesterase 7 Pseudogene" and classified explicitly as a pseudogene rather than a functional gene or protein[5]. Pseudogenes are non-functional sequences in the genome that arise from previously functional genes through duplication or retrotransposition events; most lose their protein-coding ability due to accumulated disabling mutations such as frameshifts or premature stop codons[1][3]. This specific pseudogene is related to the **phosphodiesterase 7 (PDE7) gene family**, which includes functional genes such as PDE7A and PDE7B. These functional genes encode cAMP-specific phosphodiesterases that play roles in regulating cyclic AMP levels, but the pseudogene form **does not produce a functional enzyme or receptor**[2][4][5]. As a pseudogene, it is *not* considered a therapeutic target, and there are no known biological functions, disease associations, interacting drugs, mechanisms of action, biomarker uses, or documented safety concerns directly related to this locus[5]. Further Notes: - The existence of a pseudogene does not imply retained biological activity; it largely serves as "genomic fossil" unless otherwise shown to have regulatory RNA or non-coding functional relevance, which there is currently no evidence for in this entry[1][3]. - The entry is considered "incorrect" for the context of therapeutic targeting because it does *not* represent an active receptor, enzyme, transporter, or other canonical druggable target.

Other names

PDE7 pseudogenePDE7Pphosphodiesterase 7 processed pseudogene