Phosphodiesterase 7B (PDE7B)

Phosphodiesterase 7B (PDE7B) is a 446-amino acid enzyme with a molecular mass of ~50 kDa, most highly expressed in pancreas, brain, heart, thyroid, skeletal muscle, and other tissues. It hydrolyzes cAMP to 5'-AMP, regulating physiological processes dependent on cyclic nucleotide signaling. PDE7B belongs to the PDE7 gene family and has high affinity for cAMP, with little activity for cGMP. PDE7B is inhibited in vitro by several nonselective and semiselective phosphodiesterase inhibitors, supporting its characterization as a druggable target. Its biological and potential disease roles are subject to ongoing investigation, including speculation about implication in pancreatic function, neural activity, and inflammatory signaling.

Other names

PDE7B3',5'-cyclic-AMP phosphodiesterase 7BcAMP-specific phosphodiesterase 7BbA472E5.1high-affinity cAMP-specific 3',5'-cyclic phosphodiesteraserolipram-insensitive phosphodiesterase type 7

Inhibition of PDE7B increases intracellular cAMP, affecting downstream cell signaling Drugs act as competitive inhibitors of the catalytic domain