Phosphodiesterase 8B pseudogene

The phosphodiesterase 8B pseudogene (ENSG00000259743; LOC100419366) is a genomic sequence similar to the protein-coding phosphodiesterase 8B gene but is not believed to produce a functional protein. Pseudogenes arise from gene duplication or retrotransposition events and generally lack protein-coding potential due to the presence of disabling mutations or lack of transcription[6]. There is no evidence in the provided sources or major genomic databases that this pseudogene is a functional therapeutic target, encodes an active enzyme, or is involved in disease. The functional, protein-coding version—Phosphodiesterase 8B (PDE8B)—is a cAMP-specific phosphodiesterase involved in thyroid and adrenal physiology, but the pseudogene version serves no known active biological or pathological role.\n\nKey clarifications:\n- This entry is a **pseudogene**, not a protein-coding gene or an active therapeutic target[6].\n- There is no evidence supporting any role for this pseudogene in drug interaction, disease, or regulatory function.\n- Any reference to functional roles or disease association (such as adrenal disorders or thyroid function) applies to the true PDE8B gene, not to this pseudogene[2][4][6].\n\nIf you intended to refer to the functional gene, use **"Phosphodiesterase 8B (PDE8B)"**; if you specifically meant ENSG00000259743/LOC100419366, note that this designates the **noncoding pseudogene**, which is not a target.

Other names

ENSG00000259743LOC100419366phosphodiesterase 8B pseudogene