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Phosphodiesterase 9 (PDE9)

Target: PDE9
Molecular classification: Enzyme, Phosphodiesterase

Overview

Phosphodiesterase 9 (PDE9) is a phosphodiesterase enzyme that specifically hydrolyzes cyclic GMP (cGMP), playing a crucial role in regulating intracellular cGMP levels in tissues like the heart, brain, and adipose tissue. It is a therapeutic target for conditions such as heart failure, cognitive impairment, and metabolic disorders. Inhibition of PDE9 leads to increased myocardial cGMP levels and has demonstrated potential for reversing/preventing cardiac hypertrophy and dysfunction, improving cognitive function, and enhancing metabolic health.

Mechanism of action

Selective inhibition of PDE9, leading to increased intracellular cGMP levels.

Biological functions

Hydrolyzes cGMPRegulation of cGMP signaling

Disease associations

Heart failureCognitive impairmentObesityMetabolic disorders

Interacting drugs

PF-04749982

1 more in the full profile.

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