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Target intelligence / Profile preview
Phosphodiesterase 9 (PDE9)
- Target
- PDE9
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
Phosphodiesterase 9 (PDE9) is a phosphodiesterase enzyme that specifically hydrolyzes cyclic GMP (cGMP), playing a crucial role in regulating intracellular cGMP levels in tissues like the heart, brain, and adipose tissue. It is a therapeutic target for conditions such as heart failure, cognitive impairment, and metabolic disorders. Inhibition of PDE9 leads to increased myocardial cGMP levels and has demonstrated potential for reversing/preventing cardiac hypertrophy and dysfunction, improving cognitive function, and enhancing metabolic health.
02
Mechanism of action
Selective inhibition of PDE9, leading to increased intracellular cGMP levels.
03
Biological functions
Hydrolyzes cGMPRegulation of cGMP signaling
04
Disease associations
Heart failureCognitive impairmentObesityMetabolic disorders
05
Interacting drugs
PF-04749982
1 more in the full profile.
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