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Phosphodiesterase type III (PDE3)
- Target
- PDE3
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
Phosphodiesterase type III (PDE3) is an enzyme family that hydrolyzes the second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), playing a crucial role in regulating intracellular signaling pathways. PDE3 is particularly significant in cardiovascular tissues, where it modulates heart muscle contractility, vascular smooth muscle tone, and platelet aggregation.
- Other names
- PDE III
02
Mechanism of action
Inhibition of PDE3 increases intracellular cAMP and cGMP levels, leading to increased cardiac contractility and vasodilation. In platelets, increased cAMP inhibits aggregation through PKA activation.
03
Biological functions
Hydrolyzes cAMPHydrolyzes cGMPRegulation of cardiac contractilityRegulation of vascular smooth muscle toneRegulation of platelet aggregationSignal transduction
04
Disease associations
Cardiovascular diseaseHeart failurePeripheral arterial diseaseThrombocythemia
05
Safety considerations
Increased mortality with long-term use in chronic heart failureArrhythmiasMyocyte apoptosis
06
Interacting drugs
Amrinone
4 more in the full profile.
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