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Phosphoenolpyruvate Carboxykinase (PEPCK)
- Target
- PEPCK
- Molecular classification
- Enzyme
01
Overview
Phosphoenolpyruvate carboxykinase (PEPCK) is a key enzyme in gluconeogenesis, catalyzing the conversion of oxaloacetate to phosphoenolpyruvate. It exists in cytosolic (PEPCK-C) and mitochondrial (PEPCK-M) isoforms, playing crucial roles in glucose homeostasis, glyceroneogenesis, and amino acid metabolism. Dysregulation of PEPCK is implicated in metabolic disorders such as type 2 diabetes and hypoglycemia, making it a potential therapeutic target.
- Other names
- PEPCK-CPEPCK-MPCK1PCK2
02
Mechanism of action
Inhibition of PEPCK activity
03
Biological functions
GluconeogenesisGlyceroneogenesisSerine biosynthesisAmino acid metabolismCitric acid cycle regulationInsulin secretion regulation
04
Disease associations
Type 2 diabetes mellitusHypoglycemiaMetabolic disorders
05
Safety considerations
Potential for hypoglycemia with excessive inhibitionDysregulation of glucose homeostasis
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