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Phosphofructokinase (PFK)
- Target
- PFK
- Molecular classification
- Enzyme
01
Overview
Phosphofructokinase (PFK) is a key regulatory enzyme in the glycolytic pathway, responsible for catalyzing the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ATP. It acts as a metabolic gatekeeper controlling glucose breakdown rate according to cellular needs. PFK exists as a homotetramer in bacteria and mammals and is allosterically regulated by ATP, AMP, and fructose 2,6-bisphosphate.
02
Mechanism of action
Allosteric regulation of glycolysis
03
Biological functions
GlycolysisMetabolic regulationEnergy homeostasis
04
Disease associations
Glycogen storage disease type VII (Tarui's disease)
05
Safety considerations
Exercise intolerance in PFK deficiency
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