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Phosphogluconate Dehydrogenase (6PGD)
- Target
- 6PGD
- Molecular classification
- Enzyme
01
Overview
Phosphogluconate dehydrogenase is a key enzyme in the oxidative branch of the pentose phosphate pathway (PPP), catalyzing the oxidative decarboxylation of 6-phosphogluconate to ribulose-5-phosphate, producing NADPH and CO₂. It is essential for generating ribulose-5-phosphate for nucleotide synthesis and NADPH required for reductive biosynthesis and antioxidative defense. Altered activity is implicated in cancer and neurodegenerative diseases, making it a potential therapeutic target.
- Other names
- 6PGDHPGDHPDH[2][3]
02
Mechanism of action
Inhibition of 6-phosphogluconate dehydrogenase to reduce NADPH production and anabolic biosynthesis.
03
Biological functions
Redox balanceNucleotide biosynthesisLipid biosynthesisAntioxidative defensePentose phosphate pathway
04
Disease associations
CancerNeurodegenerative disease
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