Phosphogluconate dehydrogenase pseudogene 1 (PGDP1)

Phosphogluconate dehydrogenase pseudogene 1 (PGDP1) is annotated as a pseudogene—the genetic remnant of what was once a protein-coding gene but has lost the ability to encode a functional enzyme. Unlike its functional counterpart, PGD (phosphogluconate dehydrogenase), which catalyzes a critical step in the pentose phosphate pathway and has well-characterized roles in redox biology and metabolism, PGDP1 does not contribute to enzymatic activity, disease, or drug interactions. No evidence supports a role for PGDP1 as a therapeutic target or biomarker. Its classification as a pseudogene means it typically serves as a non-functional genomic element, although in some cases pseudogenes can have regulatory roles; however, no such function has been established for PGDP1[7]. Context: - Phosphogluconate dehydrogenase (PGD) is a well-studied *enzyme* (not a pseudogene) involved in the pentose phosphate pathway and is of metabolic and potential clinical interest in fields such as cancer[1][3][5][7]. **PGDP1 is not the same entity and does not encode this enzyme.** - Pseudogenes like PGDP1 are common in the human genome and can be useful in evolutionary studies or as molecular markers, but they are not drug targets or functional proteins. If you sought information on the *functional* phosphogluconate dehydrogenase instead, please specify PGD, not PGDP1.

Other names

PGDL1phosphogluconate dehydrogenase-like 1PGDP1