Phosphoglycerate kinase 1 pseudogene

The phosphoglycerate kinase 1 pseudogene is a **nonfunctional genomic sequence** that closely resembles the protein-coding phosphoglycerate kinase 1 (PGK1) gene but does not encode a protein product[3][4]. Pseudogenes such as this arise by duplication or retrotransposition of functional genes and accumulate mutations that prevent their expression or the production of a functional protein[5]. Unlike the canonical PGK1 gene, which is a key glycolytic enzyme involved in cellular energy metabolism, the pseudogene has no known biological, enzymatic, or disease-related function[3][7]. As a result, it is not considered a therapeutic target, does not interact with drugs, and is not associated with human disease. This entry refers to a **pseudogene**, not to the canonical or druggable **phosphoglycerate kinase 1 (PGK1)** enzyme, which has clinical and biological significance[3][5][7].

Other names

PGK1P