Phosphoglycerate kinase 2 (PGK2)

Phosphoglycerate kinase 2 (PGK2) is a testis-specific isozyme of the glycolytic enzyme phosphoglycerate kinase, encoded by an autosomal retrogene and expressed during spermatogenesis[3][5]. PGK2 catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, coupled with the generation of ATP from ADP, representing an essential step in glycolysis critical for providing ATP required for sperm motility[3][5]. Its expression replaces that of the ubiquitously expressed PGK1 during spermatogenesis as the X chromosome (harboring PGK1) is inactivated in developing sperm. The crystal structure of PGK2 closely resembles that of PGK1, with two domains forming a characteristic hinge-bending structure necessary for catalytic activity[3][5]. Dysfunction or absence of PGK2 impairs sperm energy metabolism and can lead to male infertility, but there is no strong evidence for involvement in other disease states. There are currently no clinically approved drugs targeting PGK2[3][5].

Other names

Phosphoglycerate kinase, testis specificPGKBPGKPSPGK-2HEL-S-272dJ417L20.2epididymis secretory protein Li 272phosphoglycerate kinase autosomal pseudogenetesticular tissue protein Li 139

Competitive inhibitors (theoretically, ATP analogues or 3-phosphoglycerate analogues can inhibit the enzyme by competing at the active site, as understood for glycolytic enzymes)