Target intelligence / Profile preview

Phosphoglycerate mutase (PGM)

Target: PGM
Molecular classification: Enzyme, Isomerase, Mutase

Overview

Phosphoglycerate mutase is an essential metabolic enzyme involved primarily in glycolysis/gluconeogenesis by interconverting phosphorylated glycerates via intramolecular phosphate transfer mechanisms that depend on either cofactors or metal ions depending on isoform type. Its importance extends beyond metabolism into disease contexts such as cancer progression.

Other names: PhosphoglyceromutaseGPM1 (Yeast)PGAM1 (Human)

Mechanism of action

Inhibition of enzymatic activity

Biological functions

GlycolysisGluconeogenesisMetabolism

Disease associations

Cancer

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