Phosphoglycerate mutase 1 pseudogene 2 (PGAM1P2)

Phosphoglycerate mutase 1 pseudogene 2 (PGAM1P2) is classified as a pseudogene, meaning it is a non-functional segment of DNA related to the phosphoglycerate mutase 1 gene due to gene duplication or retrotransposition events.[2] Unlike protein-coding genes, pseudogenes generally do not produce a functional protein and therefore are not considered viable therapeutic targets, receptors, enzymes, transporters, or other typical drug targets.[2] Phosphoglycerate mutase 1 (PGAM1) itself is a glycolytic enzyme involved in the interconversion of 3-phosphoglycerate and 2-phosphoglycerate, and may be implicated in cancer and other metabolic diseases[1]. However, PGAM1P2 does not encode a functional enzyme and has no known therapeutic relevance or involvement in pharmacology or disease[2]. PGAM1P2 is listed in genomics resources such as GeneCards and the HUGO Gene Nomenclature Committee (HGNC: 42449), but its annotation indicates it is a pseudogene, not an active gene product[2]. If there are misspellings or confusions regarding PGAM1P2 as a drug target, these should be corrected to refer either to PGAM1 (phosphoglycerate mutase 1), which is an enzyme and a potential drug target, or to clarify that PGAM1P2 is only a pseudogene and not a molecular target[2].

Other names

Phosphoglycerate mutase 1 pseudogene 2PGAM1P2