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Target intelligence / Profile preview
Phosphoglycerate mutase family member 4 (PGAM4)
- Target
- PGAM4
- Molecular classification
- Enzyme
01
Overview
Phosphoglycerate mutase family member 4 (PGAM4) is a protein-coding gene located on the X chromosome that encodes a member of the phosphoglycerate mutase enzyme family, which catalyzes a key step in glycolysis by transferring a phosphate group from 3-phosphoglycerate to 2-phosphoglycerate[1][2][4][6]. This gene appears to have arisen from retrotransposition and is intronless, but is believed to be expressed and protein-coding[1][5]. PGAM4 is X-linked and may play a fundamental role in human male reproduction, potentially escaping meiotic sex chromosome inactivation[4]. PGAM4 is not generally recognized as a major therapeutic target or as having interacting drugs or established safety concerns; its clinical relevance appears secondary and mainly research-focused[1][4][6].
- Other names
- Probable phosphoglycerate mutase 4PGAM4dJ1000K24.1PGAM1PGAM3PGAM-Bphosphoglycerate mutase 4phosphoglycerate mutase family 3phosphoglycerate mutase processed protein
02
Biological functions
Glycolytic processIntramolecular phosphotransferase activity
03
Disease associations
Other (associated with Menkes disease and atrial septal defect 1, but not a prominent disease driver)
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