Target intelligence / Profile preview

Phosphoinositide 3-Kinase–AKT Pathway

Molecular classification: Signaling pathway

Overview

The phosphoinositide 3-kinase-AKT (PI3K-AKT) pathway is a highly conserved intracellular signaling cascade that plays a central role in regulating diverse cellular processes, including metabolism, growth, proliferation, survival, protein synthesis, transcription, and apoptosis. It is activated by various extracellular signals such as growth factors (e.g., EGF), hormones (e.g., insulin), cytokines, and other stimuli through receptor tyrosine kinases (RTKs), G-protein-coupled receptors (GPCRs), integrins, and immune cell receptors. Dysregulation or hyperactivation of this pathway is implicated in many diseases.

Biological functions

Signal transductionCell survivalCell proliferationCell growthGlucose metabolismApoptosisProtein synthesisAngiogenesisCell cycle progression

Disease associations

CancerMetabolic DisordersCardiovascular diseaseNeurological disorders

Beyond the preview

Go deeper on Phosphoinositide 3-Kinase–AKT Pathway.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Phosphoinositide 3-Kinase–AKT Pathway.

Explore the full profile