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Phosphoinositide 3-kinase beta isoform (PI3Kβ)
- Target
- PI3Kβ
- Molecular classification
- Enzyme, Kinase, Phosphoinositide 3-kinase, Class IA PI3K
01
Overview
PI3Kβ is a class IA phosphoinositide 3-kinase catalytic subunit that plays critical roles in cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking. It integrates signals from receptor tyrosine kinases (RTKs), G protein–coupled receptors (GPCRs), and Rho-family small GTPases. PI3Kβ regulates invadopodia maturation in tumor cells and is essential for osteoclast development/function. Dysregulation or mutation contributes to cancer progression/metastasis and bone disorders. It is ubiquitously expressed but has particularly important functions in reproductive organs, immune cells, bone-resorbing osteoclasts and platelets.
- Other names
- PIK3CBp110beta
02
Mechanism of action
PI3Kβ inhibitors
03
Biological functions
Cell growthCell proliferationCell differentiationCell motilityCell survivalIntracellular traffickingSpermatogenesisMacrophage functionOsteoclast functionNeutrophil functionPlatelet functionInvadopodia maturationBone homeostasis
04
Disease associations
CancerCancer progressionCancer metastasisBone disorders
05
Safety considerations
Potential for on-target and off-target effects due to the ubiquitous expression of PI3Kβ and its role in multiple cellular processes.Inhibition may lead to impaired osteoclast function and bone homeostasis.
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