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Target intelligence / Profile preview
Phosphoinositide 3-kinase delta (PI3Kδ)
- Target
- PI3Kδ
- Molecular classification
- Enzyme, Lipid kinase, Phosphoinositide 3-kinase
01
Overview
Phosphoinositide 3-kinase delta (PI3Kδ), also known as p110δ, is a lipid kinase that plays a crucial role in immune cell function, regulating cell growth, proliferation, differentiation, survival, and motility. It is highly expressed in leukocytes, particularly B cells and T cells, where it mediates signaling downstream of antigen receptors. Dysregulation of PI3Kδ is associated with immunodeficiency syndromes and cancer, making it an important therapeutic target. Selective inhibitors like idelalisib have been developed for treating hematologic malignancies.
- Other names
- p110δPIK3CDPhosphatidylinositol 3-kinase catalytic subunit delta isoform
02
Mechanism of action
Selective inhibition of PI3Kδ kinase activity, blocking downstream signaling pathways such as AKT/mTOR.
03
Biological functions
Signal transductionCell growthCell proliferationCell differentiationCell survivalCell motilityImmune responseB-cell receptor (BCR) signalingT-cell receptor (TCR) signaling
04
Disease associations
Activated PI3Kδ syndrome (APDS)ImmunodeficiencyLymphoproliferationAutoimmunityLymphomaCancerHematologic malignancies
05
Safety considerations
Immune-related adverse eventsInfectionsElevated liver enzymes
06
Interacting drugs
Idelalisib
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