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Target intelligence / Profile preview
Phosphoinositide 3-Kinase Family Protein (PI3K)
- Target
- PI3K
- Molecular classification
- Enzyme, Kinase, Lipid Kinase
01
Overview
Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate the 3' hydroxyl group of phosphatidylinositol lipids. They play a crucial role in various cellular processes, including cell growth, proliferation, survival, motility, and intracellular trafficking. PI3Ks are classified into three main classes based on their structure and substrate specificity. The pathway is tightly regulated by opposing lipid phosphatases such as PTEN. Dysregulation of the PI3K pathway is implicated in cancer and other diseases, making it a therapeutic target.
- Other names
- Phosphatidylinositol 3-KinasePI3 Kinase
02
Mechanism of action
Inhibition of PI3K kinase activity, blocking downstream signaling pathways.
03
Biological functions
Cell growthCell proliferationCell survivalCell motilityCell differentiationIntracellular traffickingImmune responseSignal transductionAutophagy regulationMetabolism
04
Disease associations
CancerImmune disordersInflammation
05
Safety considerations
HyperglycemiaRashDiarrheaNeutropenia
06
Interacting drugs
PI3K inhibitors
07
Biomarkers
PIK3CA mutationsPTEN loss
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