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Phosphoinositide 3-kinase Pathway (PI3K pathway)
- Target
- PI3K pathway
- Molecular classification
- Signal Transduction Pathway, Kinase Signaling Pathway
01
Overview
The phosphoinositide 3-kinase (PI3K) pathway is a critical intracellular signaling cascade that regulates diverse cellular processes, including cell growth, proliferation, survival, metabolism, and angiogenesis. It is activated by various extracellular signals such as growth factors, cytokines, and hormones. Dysregulation of the PI3K pathway is frequently observed in human cancers, making it an attractive target for cancer therapy development.
- Other names
- PI3K-Akt-mTOR pathwayPI3K/AKT/mTOR pathway
02
Mechanism of action
Small molecule inhibitors targeting specific PI3K isoforms or downstream effectors like AKT/mTORC2
03
Biological functions
Cell proliferationCell growthCell survivalMetabolismAngiogenesisApoptosis inhibitionProtein synthesisGlucose uptake
04
Disease associations
CancerImmune disordersMetabolic diseases
05
Safety considerations
HyperglycemiaRashDiarrheaPneumonitisImmunosuppression
06
Interacting drugs
PI3K inhibitors (e.g., Idelalisib, Alpelisib)
2 more in the full profile.
07
Biomarkers
PTEN lossPIK3CA mutationsAKT phosphorylation status
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