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Target intelligence / Profile preview
Phosphoinositide 3-kinase-protein kinase B pathway (PI3K-Akt pathway)
- Target
- PI3K-Akt pathway
- Molecular classification
- Signaling pathway
01
Overview
The Phosphoinositide 3-kinase-protein kinase B (PI3K-Akt) pathway is a central intracellular signaling pathway that regulates key cellular processes such as metabolism, growth, proliferation, survival, angiogenesis, and protein synthesis. It is activated by various extracellular signals and plays a critical role in both normal physiology and disease states including cancer.
- Other names
- PI3K-Akt signaling pathwayPI3K/Akt pathwayPI3K/PKB pathway
02
Mechanism of action
Not applicable for an entire pathway
03
Biological functions
Metabolism regulationGrowth regulationCell proliferationCell survivalAngiogenesisProtein synthesisCell cycle progressionImmune responseNeural plasticityStem cell fate determination
04
Disease associations
CancerImmune disordersNeurological disorders
05
Safety considerations
Overactivation leads to unchecked proliferation and reduced apoptosisModulates immune responsesInfluences stem cell fate
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