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Target intelligence / Profile preview
Phosphoinositide 3-kinase-Protein Kinase B Signaling Pathway (PI3K/Akt pathway)
- Target
- PI3K/Akt pathway
- Molecular classification
- Signaling pathway
01
Overview
The PI3K/Akt signaling pathway is an intracellular cascade that regulates key cellular processes such as growth, proliferation, survival, metabolism, and apoptosis. It is frequently dysregulated in diseases like cancer and diabetes. Activation involves growth factors binding to receptor tyrosine kinases (RTKs) or G protein-coupled receptors (GPCRs), leading to PI3K activation, PIP3 production, Akt recruitment/activation, and downstream effects on various cellular functions. The pathway is negatively regulated by PTEN and protein phosphatases. Therapeutic targeting is an area of intense research.
- Other names
- PI3K-Akt signaling pathwayPI3K/AKT/mTOR pathway
02
Mechanism of action
Inhibition of PI3K, Akt, or downstream targets to reduce signaling.
03
Biological functions
Signal transductionCell growthCell proliferationCell survivalApoptosis inhibitionMetabolic regulationTranscription and translation regulationImmune response
04
Disease associations
CancerDiabetesMetabolic diseasesInflammation
05
Safety considerations
Off-target effects due to broad expression of pathway components.Development of resistance to targeted therapies.Metabolic side effects (e.g., hyperglycemia, hyperlipidemia).Immune-related adverse events.
06
Interacting drugs
PI3K inhibitors
2 more in the full profile.
07
Biomarkers
Expression levels of PI3K isoformsPhosphorylation status of Akt (Thr308, Ser473)PTEN expression/activityPIP3 levels
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