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Target intelligence / Profile preview
Phosphoinositide-dependent protein kinase 1 (PDK1)
- Target
- PDK1
- Molecular classification
- Enzyme, Kinase, AGC kinase
01
Overview
Phosphoinositide-dependent protein kinase 1 (PDK1), also known as PDPK1, is a serine/threonine kinase that plays a central role in cell signaling, growth, and survival. It acts as a "master" upstream kinase that phosphorylates and activates several members of the AGC family of protein kinases, including Akt/PKB, S6 Kinase(s), and RSK. PDK1 functions downstream of PI3-Kinase signaling and its activity is crucial for regulating cell size and development. Small-molecule inhibitors have been developed targeting either the ATP-binding pocket or allosteric sites.
- Other names
- PDPK1
02
Mechanism of action
Competitive inhibition at ATP-site or allosteric modulation
03
Biological functions
Cell signalingCell growth regulationCell survivalmTOR pathway activationAuxin transport regulation
04
Disease associations
Cancer
05
Interacting drugs
Small-molecule inhibitors (ATP-binding pocket)
1 more in the full profile.
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