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Phosphoinositide kinase, FYVE-type zinc finger containing (PIKFYVE)
- Target
- PIKFYVE
- Molecular classification
- Enzyme, Lipid Kinase
01
Overview
PIKfyve is a lipid kinase that phosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) to generate phosphatidylinositol 3,5-bisphosphate [PI(3,5)P₂]. It also plays a role in the production of phosphatidylinositol 5-phosphate [PI(5)P]. These phosphoinositides are critical regulators of endosome–lysosome–autophagy signaling pathways and vesicular trafficking. PIKfyve dysfunction is linked to defects in vesicle trafficking/endolysosomal system and is implicated in neurodegenerative disorders, several cancers, and viral entry.
- Other names
- PIP5K3FYV1
02
Mechanism of action
Inhibition of PIKfyve kinase activity, disrupting TLR signaling and endolysosomal pathways.
03
Biological functions
Endolysosomal trafficking/fissionIon homeostasisAutophagy regulationVesicular trafficking
04
Disease associations
NeurodegenerationCancerViral infection
05
Safety considerations
Cytoplasmic vacuolation due to defective lysosome fission/homeostasis
06
Interacting drugs
Apilimod
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