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Phosphoinositide kinase, FYVE-type zinc finger containing enzyme (PIKfyve)
- Target
- PIKfyve
- Molecular classification
- Enzyme, Lipid Kinase, Protein Kinase, Zinc-binding protein
01
Overview
Phosphoinositide kinase, FYVE-type zinc finger containing enzyme (PIKfyve) is a lipid and protein kinase that plays a crucial role in endomembrane homeostasis. It phosphorylates phosphatidylinositol 3-phosphate [PtdIns(3)P] to generate phosphatidylinositol (3,5)-bisphosphate [PtdIns(3,5)P₂], and also produces phosphatidylinositol 5-phosphate (PtdIns5P). These products regulate vesicular trafficking pathways and lysosome fission. Dysfunctions are linked to corneal dystrophy fleck type and potentially other cellular dysfunctions.
- Other names
- 1-phosphatidylinositol-3-phosphate 5-kinasePIP5K3ZFYVE29Phosphoinositide kinase FYVE-type zinc finger containingPIPkin IIIPIPKIIIKIAA0981CFDFAB1HEL37
02
Mechanism of action
Inhibition of PIKfyve leads to impaired synthesis of PtdIns(3,5)P₂ and subsequent lysosome enlargement and cytoplasmic vacuolation.
03
Biological functions
Phosphoinositide metabolismEndosomal sorting/traffickingVesicular traffickingLysosome maintenanceZinc ion binding
04
Disease associations
Corneal dystrophy fleck typeNeurodegenerative disease (potential)Metabolic disorders (potential)
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