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Phosphoinositide kinase FYVE-type zinc finger containing enzyme (PIKfyve)
- Target
- PIKfyve
- Molecular classification
- Lipid Kinase, Enzyme
01
Overview
Phosphoinositide kinase FYVE-type zinc finger containing enzyme (PIKfyve) is a lipid kinase that phosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) to generate phosphatidylinositol 3,5-bisphosphate [PI(3,5)P₂] and synthesizes phosphatidylinositol 5-phosphate [PI(5)P]. It plays a crucial role in regulating vesicular trafficking within the endosomal–lysosomal system, including lysosome fission and reformation, and retrograde transport. Disruption or inhibition leads to defects in membrane trafficking, ion homeostasis within lysosomes, vacuole/lysosome enlargement, impaired granule biogenesis, defective cell migration, and altered immune responses. Pharmacological inhibitors are used to probe roles in viral replication cycles and other cellular processes.
- Other names
- PIP5K3
02
Mechanism of action
Inhibition of PIKfyve kinase activity
03
Biological functions
Vesicular traffickingEndosomal–lysosomal system regulationPhospholipid signalingLysosome fission and reformationRetrograde transport from endosomes to the trans-Golgi networkCell migrationSecretory granule biogenesis and maintenance
04
Disease associations
Lysosomal storage disorders-like phenotypesNeurodegenerative diseasesViral replicationCancer
05
Safety considerations
Pathological vacuolationDefects in membrane traffickingAltered ion homeostasis within lysosomes
06
Interacting drugs
PIKfyve inhibitors
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