Phospholipase A and acyltransferase 2 (PLAAT2)

Phospholipase A and acyltransferase 2 (PLAAT2) is a bifunctional enzyme with both phospholipase and acyltransferase activity, catalyzing the hydrolysis of fatty acids from phospholipids (particularly at sn-1 and sn-2 positions), as well as transferring acyl groups between lipid molecules. PLAAT2 is calcium-independent and can function as a tumor suppressor, regulating cell membrane lipid composition and influencing cell proliferation and survival. It has been implicated in cancer, Poland syndrome, and cystinuria. As a member of the HRASLS family, PLAAT2’s dual enzymatic activities allow it to play a role in lipid metabolism, membrane remodeling, and potentially in cell signaling and apoptosis.

Other names

HRASLS2FLJ20556PLAAT-2HRAS-like suppressor 2phospholipase A/acyltransferase-2PLA1/2-2

For hypothetical drugs targeting PLAAT2, mechanisms would include inhibition or modulation of its phospholipase or acyltransferase activities, potentially affecting lipid metabolism or phospholipid-mediated signaling pathways.