Phospholipase A2-activating protein (PLAA)

Phospholipase A2-activating protein (PLAA) is a multifunctional regulatory and signaling protein that facilitates the activation of cytosolic phospholipase A2 (cPLA2), leading to the synthesis of crucial inflammatory lipid mediators such as prostaglandin E2 and interleukins in response to cytokines like TNF-α[1][4]. PLAA enables these activities in part through ubiquitin binding and interaction with the AAA ATPase p97, linking it to protein quality control and ubiquitin signaling pathways, including autophagic clearance of damaged organelles[1][3]. In neurons, PLAA promotes removal of ubiquitinated proteins and supports synaptic vesicle recycling, while in peripheral tissues its decreased expression is associated with enhanced metastatic behavior in ovarian cancer, where it potentially restrains migration and invasion by modulating Ca2+ signaling[1]. Genetic disruption of PLAA is associated with severe neurodevelopmental leukoencephalopathy and altered inflammatory mediator production, highlighting its essential roles in both nervous and immune system homeostasis[1][3][4].

Other names

PLAPPLA2PFLJ11281FLJ12699DOA1DOA1 homologNDMSBAUfd3phospholipase A-2-activating proteinDOA1 homolog (S. cerevisiae)