Phospholipase A2 group IB (PLA2G1B)

Phospholipase A2 group IB (PLA2G1B) is a secreted, pancreatic enzyme of the phospholipase A2 family, primarily responsible for catalyzing the hydrolysis of the sn-2 position of glycerophospholipids in dietary and endogenous membranes to release fatty acids (including arachidonic acid) and lysophospholipids. This reaction is calcium-dependent and represents a key step in lipid digestion and in the production of bioactive lipid mediators (such as prostaglandins and leukotrienes), which play diverse roles in inflammation, immune regulation, and cellular signaling[1][2][3]. PLA2G1B is synthesized by pancreatic acinar cells and is also implicated in the modulation of immune cell signaling and in certain pathologies including chronic pancreatitis, cancer, obesity, and infectious disease. It has been studied as a potential therapeutic target due to its central role in lipid mediator biosynthesis and inflammation, although therapeutic inhibition poses challenges due to widespread physiological functions and lack of selective inhibitors[1][2][3].

Other names

Phospholipase A2, group IB (pancreas)PLA2PLA2APPLA2Group IB phospholipase A2Phosphatidylcholine 2-acylhydrolase 1BSecretory phospholipase A2 group IBPancreatic sPLA2

Inhibitors block hydrolysis of the sn-2 ester bond in phospholipids, reducing production of arachidonic acid and downstream eicosanoids - Some inhibitors block calcium binding, essential for enzymatic activity