Phospholipase A2 group IB (PLA2G1B) (PLA2G1B)

Phospholipase A2 group IB (PLA2G1B) is a calcium-dependent secretory enzyme primarily synthesized in the pancreas as an inactive zymogen and activated by trypsin in the duodenum (UniProt P04054). Its primary physiological role is the digestion of dietary phospholipids into lysophospholipids and free fatty acids, facilitating lipid absorption (PMID: 22561061). Beyond digestion, PLA2G1B acts as a ligand for the phospholipase A2 receptor (PLA2R1), influencing cell proliferation, migration, and hormone release (PMID: 11035015). Pathologically, elevated levels are associated with acute pancreatitis and chronic metabolic conditions; research indicates that PLA2G1B deficiency or inhibition can protect against diet-induced obesity and insulin resistance (PMID: 25624355). In the context of drug development, it is targeted to manage inflammatory cascades and metabolic disorders, though achieving isoform specificity remains a significant challenge (PubChem CID 155160).

Other names

Secretory phospholipase A2 group IBPancreatic phospholipase A2Phosphatidylcholine 2-acylhydrolase 1BsPLA2-IBPLA2G1B

Inhibition of the enzymatic hydrolysis of the sn-2 ester bond of phospholipids, preventing the release of free fatty acids and lysophospholipids (PMID: 11035015).