Phospholipase A2 group IVE (PLA2G4E)

Phospholipase A2 group IVE (PLA2G4E) is a cytosolic, calcium-dependent N-acyltransferase enzyme in the group IV phospholipase A2 family. Unlike classical phospholipase A2 enzymes which primarily hydrolyze the sn-2 fatty acid from phospholipids, PLA2G4E is noteworthy for mediating the transfer of the sn-1 fatty acyl chain from phosphatidylcholine to the amine group of phosphatidylethanolamine, generating N-acyl phosphatidylethanolamine (NAPE). NAPE is the precursor to bioactive N-acyl ethanolamines, including anandamide, a key endocannabinoid. This enzyme has additional weak phospholipase A2 and lysophospholipase activities, and plays an important role in intracellular membrane trafficking, especially by promoting tubule formation for clathrin-independent endocytotic recycling. Mutations in PLA2G4E have been associated with rare syndromes such as Oliver-McFarlane syndrome and cerebral creatine deficiency syndrome 3. While members of the broader phospholipase A2 family are implicated in inflammatory processes and are drug targets, no approved drugs currently target PLA2G4E specifically[3][4][1].

Other names

Cytosolic phospholipase A2 epsiloncPLA2-epsilonFLJ45651Calcium-dependent N-acyltransferasePA24E (according to UniProt)PLA2G4EN-acyltransferaseNAPE synthase