Phospholipase A2 inhibitory protein

Phospholipase A2 inhibitory proteins are a group of regulatory proteins that inhibit the enzymatic activity of phospholipase A2 (PLA2). The most well-characterized member is **lipocortin** (also known as **annexin 1**), which is upregulated by glucocorticoids and acts to suppress inflammation by blocking PLA2-mediated hydrolysis of membrane phospholipids. This inhibition prevents the release of arachidonic acid, thereby reducing the production of pro-inflammatory eicosanoids such as prostaglandins and leukotrienes[1]. These proteins play an important role in modulating immune responses and are considered potential therapeutic targets for controlling excessive inflammation. --- **Notes on correctness:** The term "phospholipase A2 inhibitory proteins" is not a single canonical target but rather refers to a class or family. The best-known example is lipocortin/annexin 1. If you require structured data for drug discovery or bioinformatics purposes, it would be more accurate to use "Annexin 1" or "Lipocortin" as the canonical name for this target. The current entry is too broad; thus, `is_incorrect` is set to true because it does not refer to one specific molecular entity but rather a functional group with several members[1].

Other names

LipocortinAnnexin 1 (for the best-known endogenous PLA2 inhibitor)PLA2 inhibitor proteinphospholipase A2 inhibitor

Inhibition of phospholipase A2 enzymatic activity, preventing release of arachidonic acid and subsequent eicosanoid synthesis[1]