Phospholipase B domain-containing protein 2 (PLBD2)

Phospholipase B domain-containing protein 2 (PLBD2) is a human lysosomal protein predicted to belong to the phospholipase B enzyme family, although its physiological substrate and precise biological function remain unconfirmed[3][1][2]. Structurally, it is an N-terminal nucleophile (NTN) hydrolase, sharing features with certain amidases and peptidases, and requires post-translational modifications including signal peptide cleavage, glycosylation, and proteolytic processing for maturation and lysosomal targeting[1][2]. PLBD2 is expressed in multiple tissues, including kidney and brain, and localizes primarily to the lysosome[5][2][3]. While mutations in the gene may theoretically contribute to lysosomal storage disorders, no definitive clinical phenotype has been ascribed[1]. The gene has several paralogs, notably PLBD1, and evidence suggests these enzymes diverged significantly following an ancient gene duplication event[1][3]. Despite extensive conservation of functional motifs, the actual activity and natural substrate of PLBD2 remain largely undetermined, and there are currently no known drugs or therapies that target this protein[1][2][3].

Other names

Putative phospholipase B-like 2p7676 kDa proteinLAMA-like protein 2Lamina ancestor homolog 2mannose-6-phosphate protein associated protein p76PLB homolog 2 (Dictyostelium)32 kDa form45 kDa formPLB homolog 2PLB-like 2phospholipase B-like 2 32 kDa formphospholipase B-like 2 45 kDa form