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Target intelligence / Profile preview
Phospholipase C-Induced Lysosomal Enzyme Release Pathway (PLC-ILER)
- Target
- PLC-ILER
- Molecular classification
- Signaling Pathway
01
Overview
Phospholipase C-induced lysosomal enzyme release refers to a cellular process in which the activation of phospholipase C (PLC) leads to the exocytosis of lysosomes and subsequent release of their enzymes into the extracellular space. This pathway is particularly relevant in immune cells such as monocytes and neutrophils, where it plays a role in inflammation, cytokine secretion (notably IL-1β), and other regulated secretory pathways.
02
Biological functions
InflammationCytokine secretionRegulated secretionLysosome exocytosis
03
Disease associations
InflammationAutoimmune diseases
04
Safety considerations
Exacerbation of inflammatory responsesUncontrolled cytokine release
05
Biomarkers
IL-1β levelsCaspase-1 levelsLysosomal enzyme levels
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