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Phospholipase D family member 4 (PLD4)
- Target
- PLD4
- Molecular classification
- Enzyme, Exonuclease, Type II transmembrane glycoprotein
01
Overview
Phospholipase D family member 4 (PLD4) is a single-stranded nucleic acid-specific exonuclease that hydrolyzes ssDNA and RNA. It is involved in immune regulation and has been associated with autoimmune conditions like SLE and cancer progression. PLD4 acts as a single-stranded nucleic acid-specific exonuclease with specificity for substrates possessing a free 5′ hydroxyl group.
- Other names
- C14orf175phospholipase D family member 4
02
Biological functions
Nucleic acid degradationImmune regulationExonuclease activityRegulation of inflammatory responses
03
Disease associations
Systemic lupus erythematosusColon cancer
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