Target intelligence / Profile preview

Phospholipase D Isoform 1 (PLD1)

Target: PLD1
Molecular classification: Enzyme, Phospholipase

Overview

Phospholipase D isoform 1 (PLD1) is an enzyme that catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid (PA) and choline. PLD1-generated phosphatidic acid plays a key role in membrane trafficking, signal transduction, and neuroendocrine function. Altered expression or function of PLD1 has been implicated in several diseases, including cancer and neurological disorders.

Mechanism of action

Phospholipase D inhibitors (Hypothetical)

Biological functions

Membrane traffickingExocytosisEndocytosisSignal transductionLipid signalingVesicle traffickingCytoskeletal regulation

Disease associations

Cancer progressionInflammationNeurodegenerative diseaseAlzheimer's disease

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