Phospholipid Membrane Permeability Enhancement

Phospholipid membrane permeability enhancement refers to the process of increasing the ability of molecules or ions to cross biological membranes composed primarily of phospholipid bilayers. This is a critical target in drug delivery, biotechnology, and cell biology, as it can facilitate the transport of therapeutic agents, nutrients, or other compounds into cells or across tissue barriers. Strategies involve chemical permeabilizers (e.g., SDS, DMSO), physical methods (e.g., electric fields), and thermal/phase transition approaches. The effectiveness and safety depend on concentration, membrane composition, and the specific method used.

Other names

Membrane permeabilizationCell membrane permeability enhancementLipid bilayer permeability modulation

Disruption of lipid packing, formation of transient pores, induction of membrane fluidization, alteration of phase transition temperature