Phospholipid Metabolism in Protozoa

Phospholipid metabolism in protozoan parasites encompasses the de novo synthesis, modification, and scavenging of phospholipids, which are crucial for membrane structure, host cell invasion, nutrient uptake, and immune evasion. Enzymes involved in fatty acid synthesis (FASI/FASII), phospholipases, and other lipid-modifying enzymes represent potential drug targets due to their divergence from mammalian counterparts. Targeting these pathways can disrupt membrane integrity, energy production, and replication, ultimately leading to parasite death. The clinical success of miltefosine against Leishmania validates lipid metabolism as a viable therapeutic target. However, redundancy within protozoan lipid metabolism pathways and potential off-target effects pose challenges for drug development.

Other names

Protozoan Lipid MetabolismParasitic Phospholipid Synthesis

Inhibition of lipid synthesis pathways, disruption of membrane integrity, interference with energy production