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Phospholipid Phosphatase (PLPP)
- Target
- PLPP
- Molecular classification
- Enzyme, Phosphatase, Integral membrane glycoprotein
01
Overview
Phospholipid phosphatases (PLPPs) are a family of integral membrane enzymes that catalyze the dephosphorylation of various lipid phosphate substrates, including lysophosphatidic acid (LPA), sphingosine-1-phosphate (S1P), and phosphatidic acid. These enzymes play crucial roles in regulating lipid signaling pathways, cellular uptake of bioactive lipids, and maintaining lipid homeostasis. Alterations in PLPP expression or function can impact numerous physiological processes, and dysregulation is linked with cancer progression due to effects on cell proliferation/migration pathways. In infectious disease contexts, some pathogens secrete proteins with phospholipid phosphatase activity that modulate host immune responses.
02
Mechanism of action
Dephosphorylation of bioactive lipids
03
Biological functions
Lipid metabolismLipid signalingRegulation of cell proliferationRegulation of cell migrationRegulation of cell survivalRegulation of cell differentiationLipid homeostasis
04
Disease associations
CancerInfection
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