Phospholipid scramblase 2 (PLSCR2)

Phospholipid scramblase 2 (PLSCR2) is a member of the phospholipid scramblase family, coded by the PLSCR2 gene in humans[1][4][5][6][7]. PLSCR2 is an ATP-independent, membrane-associated enzyme that likely facilitates rapid, bidirectional, calcium-dependent translocation (“scrambling” or “flip-flop”) of phospholipids, thus collapsing physiological membrane lipid asymmetry[1][4]. The protein contains a low-affinity calcium binding motif and is structurally related to other scramblases, with a conserved β-barrel structure and a palmitoylation motif for membrane anchorage[3][4]. Unlike other family members, PLSCR2 expression is largely restricted to testis[2], and its functional specificity remains somewhat unclear—some evidence suggests roles in apoptosis and blood coagulation[1], but, in contrast to PLSCR1 and PLSCR3, direct roles in signaling, transcription, or disease have not been well characterized. There are no approved drugs targeting PLSCR2, and no known clinical biomarkers or established safety concerns[1][4][6][7].

Other names

Phospholipid scramblase 2PLSCR2PL scramblase 2Ca(2+)-dependent phospholipid scramblase 2

No approved drugs; theoretical mechanisms would include modulation of lipid scrambling and downstream effects on cell membrane asymmetry and apoptosis.