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Target intelligence / Profile preview
Phospholipid-transporting ATPase VD (ATP10D)
- Target
- ATP10D
- Molecular classification
- Enzyme, Transporter, P4-ATPase, Flippase
01
Overview
Phospholipid-transporting ATPase VD (ATP10D) is a member of the P4-ATPase family, functioning as the catalytic core of a flippase complex that hydrolyzes ATP to drive the translocation of glucosylceramide and other aminophospholipids across cellular membranes, thereby maintaining membrane lipid asymmetry[6][7][1]. ATP10D is expressed in multiple tissues and localizes to the endoplasmic reticulum, nucleoplasm, and plasma membrane[1][2]. Although the full physiological and pathological significance of ATP10D in humans is still under investigation, genetic association studies suggest a role for ATP10D in lipid metabolism and cardiometabolic disorders[5]. Presently, there are no drugs known to directly target this protein, and it is not widely used as a biomarker or therapeutic target in current clinical practice.
- Other names
- ATPase phospholipid transporting 10DATPVDKIAA1487P4-ATPase flippase complex alpha subunit ATP10Dprobable phospholipid-transporting ATPase VDtype IV aminophospholipid transporting ATPase
02
Biological functions
Phospholipid translocationGlycosylceramide (GlcCer) flippase activityMaintenance of lipid asymmetry in membranesATP hydrolysis coupled transport
03
Disease associations
Cardiometabolic diseasesMetabolic syndrome (implicated via association studies); further research required for direct causal roles
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