Target intelligence / Profile preview

Phosphomevalonate Kinase (PMVK)

Target: PMVK
Molecular classification: Enzyme, Kinase, Transferase

Overview

Phosphomevalonate kinase (PMVK) is an enzyme that catalyzes the ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate 5-diphosphate, a critical step in the mevalonate pathway for sterol and isoprenoid biosynthesis. It is a potential therapeutic target for cancer and autoinflammatory diseases. Recent research highlights its role in β-catenin signaling and radiosensitization in cancer.

Other names: HUMPMKIPMKPMKAPMKASEPOROK1

Mechanism of action

Inhibition of mevalonate diphosphate production

Biological functions

Sterol biosynthesisIsoprenoid biosynthesisPhosphorylation

Disease associations

Autoinflammatory diseasesCancer

Safety considerations

Inhibition may impair embryonic developmentPotential for off-target effects due to ATP-binding motif

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