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Phosphoprotein 65 (pp65)

Target: pp65
Molecular classification: Viral structural protein, Tegument protein

Overview

The pp65 antigen, also known as phosphoprotein 65 or UL83, is a major structural protein of the human cytomegalovirus (HCMV). It is one of the most abundant proteins in the virion tegument and plays roles in virion morphogenesis, immune evasion by inhibiting type I interferon responses, and transactivation of viral immediate early genes. It's a major target for the immune response and is used as a diagnostic marker for active CMV infection.

Other names: UL83Phosphoprotein UL83Tegument protein UL83Matrix phosphoprotein pUL8365 kDa matrix phosphoprotein

Biological functions

Virion morphogenesisTegument assemblyImmune evasionTransactivation of viral genes

Disease associations

Cytomegalovirus infectionCongenital CMVMononucleosisPneumonia

Biomarkers

CMV pp65 antigenemia

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