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Phosphoprotein pp65 (pp65)
- Target
- pp65
- Molecular classification
- Viral protein, Tegument protein
01
Overview
pp65 is a major tegument phosphoprotein of human cytomegalovirus (HCMV). It plays a structural role in the virion and modulates the host's immune response by inhibiting interferon production and interfering with innate immunity. It is a major target for the host's immune response and is used in diagnostic assays and vaccine research.
- Other names
- 65 kDa phosphoproteinUL83ppUL83
02
Biological functions
Structural component of virionImmunomodulationInhibition of interferon responseScaffold for viral protein assembly
03
Disease associations
InfectionHCMV infection
04
Biomarkers
HCMV infection diagnosisHCMV vaccine researchT cell response to CMV antigens
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